21c Museum Hotel St. Louis features over 14,000 square feet of dynamic exhibition and event space, equipped with state-of-the-art technology to support events of all kinds. Whether planning a corporate retreat, reception dinner, cocktail party, charity gala, or an intimate wedding, 21c Museum Hotel St. Louis offers a versatile and inspiring setting.

With six unique indoor spaces and the option for outdoor gatherings, the hotel’s expert planning team will help bring any vision to life—while guests enjoy exceptional catering crafted by the renowned culinary team.