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Located in the heart of St. Louis, 21c Museum Hotel brings new life to the historic 1926 YMCA building, reimagined as a luxury boutique hotel and contemporary art museum. Just steps from top attractions like Enterprise Center, City Museum, Stifel Theatre, and Energizer Park, it’s the perfect home base for exploring the city—or staying in. Whether you’re here for a special event or a spontaneous getaway, enjoy 14,000 square feet of curated gallery space and the state-of-the-art amenities of the modern Locust Street Athletic Club. A destination in itself, 21c invites both travelers and locals to gather, discover, and unwind.

Nearest Airport

St. Louis Lambert International Airport (STL): 14 miles / 21 minutes.    

Hotel Address

1528 Locust Street, St. Louis

Missouri, United States 63103 


Historic Hotels of America Recommended Points of Interest


  • Gateway Arch

    Gateway Arch

    A curved, 630-ft.-tall monument celebrating US western expansion, with views from the top and also a museum. 

  • Gateway Arch Museum

    Gateway Arch Museum

    Explore the history of the American West at the Gateway Arch Museum.

  • Saint Louis Art Museum

    Saint Louis Art Museum

    Explore some of the finest art in the country at the Saint Louis Art Museum.

  • Saint Louis Zoo

    Saint Louis Zoo

    Free 90-acre zoo featuring animals such as penguins, bears & elephants, plus a train ride.

  • St. Louis Aquarium At Union Station

    St. Louis Aquarium at Union Station

     Explore the St. Louis Aquarium at Union Station, one of the most unique indoor attractions in St. Louis. 

  • Tower Grove Park

    Tower Grove Park

    Spend time outside in St. Louis at Tower Grove Park.