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Located in the heart of St. Louis, 21c Museum Hotel brings new life to the historic 1926 YMCA building, reimagined as a luxury boutique hotel and contemporary art museum. Just steps from top attractions like Enterprise Center, City Museum, Stifel Theatre, and Energizer Park, it’s the perfect home base for exploring the city—or staying in. Whether you’re here for a special event or a spontaneous getaway, enjoy 14,000 square feet of curated gallery space and the state-of-the-art amenities of the modern Locust Street Athletic Club. A destination in itself, 21c invites both travelers and locals to gather, discover, and unwind.

Nearest Airport

St. Louis Lambert International Airport (STL): 14 miles / 21 minutes.    

Hotel Address

1528 Locust Street, St. Louis

Missouri, United States 63103 


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