View our
special offers
The 21c Museum Hotel Cincinnati is the perfect place to start an adventurous journey into The Queen City. The hotel is just a short distance from several iconic destinations, including the Great American Ballpark and the Smale Riverfront Park. The hotel’s proximity to Downtown offers travelers easy access to local cultural attractions. Cincinnati/Northern Kentucky Int’l Airport: 13.4 miles, 20 minutes.

Driving Directions

  • I-75 N to West 5th St in Cincinnati.
  • Take exit 1C from I-75 N
  • Follow West 5th St to Vine St turn left
  • Turn right on 7th St
  • Turn right on Walnut St
  • 21c Museum Hotel Cincinnati will be on the left #609

Nearest Airport

Cincinnati / Northern Kentucky International Airport (CVG): 13.1 miles/16-24 minutes away

Hotel Address

609 Walnut Street, Cincinnati

Ohio, United States 45202


Historic Hotels of America Recommended Points of Interest


  • American Sign Museum

    American Sign Museum

    Explore historical American signage at the American Sign Museum.

  • Cincinnati Art Museum

    Cincinnati Art Museum

    Experience some of the finest art in the country at the Cincinnati Art Museum.

  • Cincinnati Museum Center At Union Terminal

    Cincinnati Museum Center at Union Terminal

    Discover kid-friendly activities at the Cincinnati Museum Center at Union Terminal.

  • Cincinnati Zoo & Botanical Garden

    Cincinnati Zoo & Botanical Garden

    Explore the wide variety of animals at the Cincinnati Zoo & Botanical Garden.

  • Harding Home Presidential Site

    Harding Home Presidential Site

    Discover the residence of former U.S. President Warren G. Harding.

  • Krohn Conservatory

    Krohn Conservatory

    Spend time outside in Cincinnati at the famous Krohn Conservatory.

  • Mt. Airy Forest

    Mt. Airy Forest

    Hike through the verdant Mt. Airy Forest.

  • National Underground Railroad Freedom Center

    National Underground Railroad Freedom Center

    Experience the historical legacy of the Underground Railroad.

  • Newport Aquarium

    Newport Aquarium

    Discover the aquatic life on display at the Newport Aquarium.

  • Rutherford B. Hayes Presidential Library & Museums

    Rutherford B. Hayes Presidential Library & Museums

    Experience the legacy of former U.S. President Rutherford B. Hayes.

  • Southgate Street School

    Southgate Street School

    Visit this historic school, which played host to African American students in the community from 1866 until integration in the 1950s.

  • William Howard Taft National Historic Site

    William Howard Taft National Historic Site

    Explore the home of former U.S. President William Howard Taft.